منابع مشابه
Viral DNAemia and Immune Suppression in Pediatric Sepsis.
OBJECTIVES Demonstrate that DNA viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. DESIGN Retrospective analysis of a prospective cohort study. PATIENTS Seventy-three children admitted with sepsis-induced organ failure. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS This study was performed as an ancillary inv...
متن کاملExperimental Cannabinoid 2 Receptor-Mediated Immune Modulation in Sepsis
Sepsis is a complex condition that results from a dysregulated immune system in response to a systemic infection. Current treatments lack effectiveness in reducing the incidence and mortality associated with this disease. The endocannabinoid system offers great promise in managing sepsis pathogenesis due to its unique characteristics. The present study explored the effect of modulating the CB2 ...
متن کاملBiomarkers in Pediatric Sepsis
Sepsis is a leading killer of both adult and pediatric patients, and delays in recognition and treatment significantly increase the risk of morbidity and mortality [2, 3]. The concept of early detection serves as the foundation for the search for clinically viable indicators of severe sepsis and septic shock – hence the interest in sepsis biomarkers. A biomarker is defined as the biological par...
متن کاملPediatric sepsis
Sepsis is the leading cause of death in children worldwide. Although the diagnosis and management of sepsis in infants and children is largely influenced by studies done in adults, there are important considerations relevant for pediatrics. This article highlights pediatric-specific issues related to the definition of sepsis and its epidemiology and management. We review how the capacity of the...
متن کاملPediatric Sepsis: Genetic Considerations
In addition to several other factors (e.g., type and virulence of pathogen, general condition of host, immune status), a substantial role is attributed to genetic factors in the development of pediatric sepsis. Several studies have found an association between changes in genes encoding systemic inflammatory response syndrome (SIRS) mediators and sepsis outcome. Some genetic variants can cause s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pediatric Intensive Care
سال: 2019
ISSN: 2146-4618,2146-4626
DOI: 10.1055/s-0038-1676607